Nuclear Structure featured in Cell Reports
NCXT staff and collaborators have mapped the reorganization of genetic material that takes place when a stem cell matures into a nerve cell. Detailed 3-D visualizations show an unexpected connectivity in the genetic material in a cell’s nucleus, and provide a new understanding of a cell’s evolving architecture.
These unique 3-D reconstructions of mouse olfactory cells, which govern the sense of smell, were obtained using soft x-ray tomography. The results could help us understand how patterning and reorganization of DNA-containing material called chromatin in a cell’s nucleus relate to a cell’s specialized function as specific genes are activated or silenced.
LBL Press release