Biological applications of colloidal nanocrystals

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TitleBiological applications of colloidal nanocrystals
Publication TypeJournal Article
Year of Publication2003
AuthorsParak WJ, Gerion D, Pellegrino T, Zanchet D, Micheel C, Williams SC, Boudreau R, Le Gros MA, Larabell CA, Alivisatos AP
Journal TitleNanotechnology
Volume14
PagesR15-R27
Journal DateJul
ISBN Number0957-4484
Accession NumberISI:000184660900001
Keywordsatomic force microscopy, cadmium-sulfide nanoparticles, cdse nanocrystals, cell-surface receptors, molecular recognition, optical-properties, phagokinetic tracks, self-assembled monolayers, semiconductor quantum dots, stabilized gold nanoparticles
Abstract

Due to their interesting properties, research on colloidal nanocrystals has moved in the last few years from fundamental research to first applications in materials science and life sciences. In this review some recent biological applications of colloidal nanocrystals are discussed, without going into biological or chemical details. First, the properties of colloidal nanocrystals and how they can be synthesized are described. Second, the conjugation of nanocrystals with biological molecules is discussed. And third, three different biological applications are introduced: (i) the arrangement of nanocrystal-oligonucleotide conjugates using molecular scaffolds such as single-stranded DNA, (ii) the use of nanocrystal-protein conjugates as fluorescent probes for cellular imaging, and (iii) a motility assay based on the uptake of nanocrystals by living cells.

URL<Go to ISI>://000184660900001