Quantum dots as cellular probes

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TitleQuantum dots as cellular probes
Publication TypeJournal Article
Year of Publication2005
AuthorsAlivisatos AP, Gu WW, Larabell C
Journal TitleAnnual Review of Biomedical Engineering
Volume7
Pages55-76
ISBN Number1523-9829
Accession NumberISI:000231513200003
Keywordsbiological application, biological detection, fluorescent nanocrystals, fluorescent probing, imaging, in-situ hybridization, luminescent probes, nanoparticles, phagokinetic tracks, recombinant protein, resonance energy-transfer, semiconductor nanocrystals, surface modification, tumor-cells
Abstract

Robust and bright light emitters, semiconductor nanocrystals [quantum dots (QDs)] have been adopted as a new class of fluorescent labels. Six years after the first experiments of their uses in biological applications, there have been dramatic improvements in understanding surface chemistry, biocompatibility, and targeting specificity. Many studies have shown the great potential of using quantum dots as new probes in vitro and in vivo. This review summarizes the recent advances of quantum dot usage at the cellular level, including immunolabeling, cell tracking, in situ hybridization, FRET, in vivo imaging, and other related technologies. Limitations and potential future uses of quantum dot probes are also discussed.

URL<Go to ISI>://000231513200003