Semiconductor nanocrystals for biological imaging

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TitleSemiconductor nanocrystals for biological imaging
Publication TypeJournal Article
Year of Publication2005
AuthorsFu AH, Gu WW, Larabell C, Alivisatos AP
Journal TitleCurrent Opinion in Neurobiology
Volume15
Pages568-575
Journal DateOct
ISBN Number0959-4388
Accession NumberISI:000232943500012
Keywordscdse nanocrystals, cytotoxicity, fluorescence, in-vivo, live cells, Microscopy, nanoparticles, Quantum Dots, receptors, tracking
Abstract

Conventional organic fluorophores suffer from poor photo stability, narrow absorption spectra and broad emission spectra. Semiconductor nanocrystals, however, are highly photo-stable with broad absorption spectra and narrow size-tunable emission spectra. Recent advances in the synthesis of these materials have resulted in the generation of bright, sensitive, extremely photo-stable and biocompatible semiconductor fluorophores. Commercial availability facilitates their application in a variety of unprecedented biological experiments, including multiplexed cellular imaging, long-term in vitro and in vivo labeling, deep tissue structure mapping and single particle investigation of dynamic cellular processes. Semiconductor nanocrystals are one of the first examples of nanotechnology enabling a new class of biomedical applications.

URL<Go to ISI>://000232943500012